Colorado creates a natural medicine sales license for healing centers

What changed on August 12

HB26-1325 creates a "limited regulated natural medicine sales license" so that a co-located licensee can sell to people taking part in an administration session. It also lets the Department of Revenue "temporarily waive or adjust testing requirements", adds ibogaine pilot provisions that depend on gifts, grants or donations, and "clarifies that state law does not permit" advertising natural medicine or using harm reduction or support services to make sales.¹ The final fiscal note says the bill was signed June 4, 2026; the department's emergency rule filing says June 3.^1,2

The emergency rules (1 CCR 213-1, eDocket 2026-00359) were adopted August 11, took effect August 12 and were published in the Colorado Register on September 10. A new Rule 8006 allows sales only to participants "immediately preceding their administration session" at the healing center, and not to facilitators. Emergency rules "remain in effect for 120 days from the date of adoption".³ The July 9 final fiscal note reported 40 licensed healing centers "at the time of this writing"; we haven't confirmed a current count.¹

How Colorado tests psilocybin products

Colorado's permanent natural medicine rules set the testing behind every label. Testing facilities must be certified by the state health department and accredited to ISO/IEC 17025:2017.⁴

• Tryptamine tests measure psilocybin, psilocin, baeocystin, aeruginascin and norbaeocystin. Any 4-AcO-DMT, or any synthetic or chemically converted tryptamine, is a failed test.⁴
• Harvest-lot samples must mix caps and stems from different mushrooms, so the result describes the lot rather than one mushroom.⁴
• Content is retested every nine months, and a product must be relabeled if its Total Psilocin comes back more than 15% higher or lower.⁵
• A manufactured product lot is homogeneous only if each of at least four tested servings is within 15.0% of the labeled value and their relative standard deviation is under 15.0%.⁵

What the label shows

Colorado defines Total Psilocin as psilocybin times 0.719, plus psilocin.⁴ The 0.719 factor converts psilocybin into the psilocin it could become; our psilocybin vs psilocin guide explains the chemistry. Before products go to a healing center or facilitator, labels must show the P. cubensis strain, net contents, Total Psilocin in milligrams and the date of the tryptamine test. Without shelf-stability testing, the label must say the content has to be retested every 9 months. Labels also carry a drug interaction warning and may not make health claims.⁴

Why it matters for reading milligram numbers

A milligram figure on a psilocybin label means little until you know its basis. Oregon has proposed replacing its psilocin-based total with "total psilocybin equivalent", calculated as psilocybin plus 1.4 times psilocin.⁶ For the same product, that figure comes out about 1.39 to 1.4 times Colorado's Total Psilocin (our arithmetic from the two formulas). New Mexico's proposed producer rules would put both conventions on the label.⁷ Colorado's 15% relabeling threshold also shows that a label is a measurement with a tolerance, not an exact count. Our guide to milligrams on capsule labels covers these differences.

Colorado's program is state-legal and supervised, with sessions in licensed healing centers. Psilocybin remains a Schedule I controlled substance under federal law, and ordering it online or by mail is illegal under federal law and in every state.